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When people talk about anti-ageing supplements or therapies, one name that frequently comes up is glutathione. Often called the body’s “master antioxidant”, glutathione plays a central role in cellular protection, detoxification, and longevity. But what exactly does it do, and how might it slow down the ageing process?

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What is Glutathione?

Glutathione is a tripeptide made up of three amino acids: glutamine, cysteine, and glycine. Unlike vitamins that come from food, glutathione is produced naturally within the body and found in nearly every cell.

Its primary function is to:

• Neutralise free radicals and reactive oxygen species (ROS).
• Support detoxification in the liver.
• Maintain immune system strength.
• Regenerate other antioxidants, like vitamins C and E.

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The Link Between Glutathione and Ageing

As we age, glutathione levels naturally decline, which makes cells more vulnerable to oxidative stress and inflammation—two key drivers of ageing and age-related diseases.

Research shows:

• Oxidative stress accelerates cellular damage, contributing to wrinkles, loss of elasticity, and chronic conditions like cardiovascular disease.
• Low glutathione levels are consistently found in older adults and in patients with neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s).
• Boosting glutathione can improve mitochondrial function, which helps cells produce energy more efficiently—a critical factor in longevity.

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Potential Anti-Ageing Benefits of Glutathione

1. Skin Health & Brightening
   • By reducing oxidative stress and melanin production, glutathione is often marketed for skin lightening and brightening. Some studies suggest modest improvements in skin tone and texture.
2. Cellular Protection
   • Shields DNA and proteins from free radical damage, slowing cellular wear and tear.
3. Detoxification
   • Helps neutralise environmental toxins, heavy metals, and pollutants, reducing the body’s overall toxic load.
4. Immune Support
   • A well-functioning immune system is key to healthy ageing, and glutathione is essential for white blood cell activity.

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How to Support Healthy Glutathione Levels

• Diet: Foods rich in sulfur-containing compounds (garlic, onions, cruciferous vegetables like broccoli and kale) support glutathione production.
• Supplements: Options include N-acetylcysteine (NAC), which raises glutathione indirectly, and direct liposomal or IV glutathione for higher absorption.
• Lifestyle: Adequate sleep, regular exercise, and limiting alcohol help maintain levels.
• Avoid Depletion: Chronic stress, pollution, smoking, and poor diet can all lower glutathione.

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The Bottom Line

Glutathione is central to the body’s antioxidant defense and detoxification systems. While it’s not a magic bullet for reversing ageing, maintaining healthy glutathione levels can slow oxidative damage, improve resilience, and support youthful cellular function. In short, it’s a cornerstone of healthy ageing strategies.

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