https://pmc.ncbi.nlm.nih.gov/articles/PMC7585045/

Serratiopeptidase (often referred to as serrapeptase) is a proteolytic (protein-dissolving) enzyme derived from bacteria in the digestive tract of silkworms. It has been studied for a range of potential therapeutic benefits, though it is important to note that more large-scale, well-controlled clinical research is still needed to confirm many of these effects. Below are some commonly cited therapeutic applications and benefits:

1. Anti-inflammatory Effects
   • Serratiopeptidase is frequently used to help reduce inflammation in conditions like arthritis, sinusitis, and other inflammatory states.
   • It may help lower inflammatory markers and ease discomfort associated with swelling or tissue damage.
2. Pain Relief
   • By reducing inflammation and swelling, serratiopeptidase may contribute to pain relief in conditions such as osteoarthritis, rheumatoid arthritis, and other musculoskeletal disorders.
3. Reduction of Excess Mucus
   • Some studies suggest that serratiopeptidase can thin or decrease mucus in the respiratory tract, thus potentially relieving symptoms of chronic respiratory conditions, sinusitis, or bronchitis.
4. Scar Tissue and Fibrin Breakdown
   • As a proteolytic enzyme, serratiopeptidase may help dissolve or break down fibrin and other proteins that contribute to scar tissue formation, potentially supporting wound healing or reducing scar tissue buildup.
5. Postoperative Swelling and Pain Management
   • Some practitioners use serratiopeptidase to help minimize edema, swelling, and pain after surgical procedures or injuries, which can potentially speed recovery.
6. Potential Cardiovascular Benefits
   • Early research suggests that serratiopeptidase might reduce plaque in the arteries by breaking down certain protein byproducts involved in plaque formation. However, evidence for these effects is preliminary.

Important Considerations

• Scientific Evidence: While there are studies supporting some of these therapeutic benefits, larger and more rigorous clinical trials are needed to definitively establish efficacy, optimal dosage, and safety.
• Side Effects: Potential side effects can include gastrointestinal discomfort, nausea, or changes in stool consistency.
• Interactions: Serratiopeptidase may interact with anticoagulant or antiplatelet medications (e.g., warfarin) and could alter bleeding risk. Always consult a healthcare professional for personalized guidance.
• Regulatory Status: Serratiopeptidase is not approved by the U.S. FDA for any specific medical condition and is often sold as a dietary supplement rather than a pharmaceutical product.